Role of MRI defecography in assessment of pelvic floor pathologies

Background: Functional disorders of the pelvic ?oor are a common clinical problem. Diagnosis and treatment of these disorders, which frequently manifest with nonspeci?c symptoms such as constipation or incontinence, remain dif?cult. MR Defecography has emerged over the last decade as a modality which additionally images the pelvic floor function in real time besides combining the advantages of previously used modalities and that of magnetic resonance i.e. multiplanar imaging, good temporal resolution and lack of radiation exposure. Dynamic MRI defecography is a relatively new imaging protocol which can be extremely useful in identification of anatomic and functional pelvic floor dysfunction such as organ prolapse, anismus and fecal incontinence. Excellent demonstration of the perirectal soft tissues allows assessment of spastic pelvic ?oor syndrome and descending perineum syndrome and visualization of enteroceles. The aim of the study was to assess causes of pelvic floor dysfunction.Methods: Authors evaluated 25 patients with cine Magnetic Resonance Defecography at our center between December 2018 and 15th May 2019. MR Defecography was done with help of 3 Tesla Somatom Seimens MRI. Ultrasound jelly was instilled into the rectum of patient via a short flexible tube while the patient lies in the lateral decubitus position on the scanner table before being moved into the gantry and was asked to defecate when instructed. Scanning was done in four phases-resting, straining, squeezing and defecation as per the standard protocol while patient lied supine.Results: Most common complaint encountered was that of constipation. Patients in age group 20-70 years were studied. Maximum patient were of the age group 40-50 years. Most common finding was organ prolapse in total 9 patients with anterior rectocele in 6 patients followed by rectal prolapse.Conclusions: Magnetic resonance defecography is an excellent modality for assessment of pelvic floor disorders. It has very good temporal resolution and high soft tissue contrast, also allows visualization of the pelvic floor function in real-time without any radiation load. Imaging the defecation process in real-time leads to a definitive diagnosis in cases of dysfunctional defecation and a precise diagnostic and pre-operative assessment in cases of organ prolapse.

Assessment of immunization coverage in district Srinagar of Kashmir

Background: Immunization is till now most safe, cost effective and powerful intervention that has decreased the burden of vaccine preventable infectious diseases all over the world. The aim of this study was to estimate the immunization coverage among children aged 12-23 months in district Srinagar of Jammu and Kashmir.Methods: The study sample included 30 clusters from district Srinagar selected as per the 30×7 cluster sampling method.Results: It was found that fully immunized children were 87.14% and 12.26% of children were partially immunized and none was unimmunized. Regarding the individual vaccine coverage, it was highest for OPV1 (99.52%) followed by BCG and OPV0 (99.05%) and lowest for Hepatitis birth dose (95.24%). The dropout was found highest (6.22%) for OPV1-OPV3 and lowest (1.47%) for LPV1 - measles/MCV (1.47%).Conclusions: The immunization of district Srinagar is above 85% and this gives a positive hope for better future to reach coverage of 100%.

Assessment of Thoraco-abdominal injury pattern due to blunt trauma in Kashmiri Population by contrast enhanced Computerized Tomography (CECT)

Background: The most common causes of blunt abdominal trauma are motor vehicle collisions, falls from height, assaults, and sports accidents. Computed tomographic (CT) examination of the head, neck, chest, abdomen, and pelvis has become an essential element in the early evaluation and decision-making algorithm for hemodynamically stable patients who sustained abdominal trauma. Although the decision to surgically intervene is usually based on clinical criteria rather than findings from images. CT information often increases diagnostic confidence and decreases rates of unnecessary exploratory laparotomy. Aim and objective: To study the pattern of Thoraco-abdominal injuries due to Blunt Trauma in Kashmiri population. Methods and materials: Study was done in the department of Radiodiagnosis and Imaging, GMC Srinagar. 64 patients with Positive extended FAST (focused assessment with sonography for trauma) done by expert in emergency Radiology were subjected to contrast enhanced CT. Results: According to our Study, Lung was the most commonly injured organ being injured in 67% cases followed by Spleen and Liver, being injured in 59% and 45% cases respectively. Most common pattern of lung injury was Contusion. Grade III was the most common grade of injury followed by Grade IV injury amongst splenic and liver injuries. Rib was the most commonly injured bone. Suhail Rafiq, Ishfaq Kuchay, Sheema, Sajad Dar. Assessment of Thoraco-abdominal injury pattern due to blunt trauma in Kashmiri Population by contrast enhanced Computerized Tomography (CECT). IAIM, 2019; 6(6): 23-31. Page 24 Conclusion: Multidetector CT has very high accuracy for optimal evaluation of the patients with Blunt trauma. CT plays a vital role in deciding mode of treatment whether medical or surgical for patients with blunt trauma. Lung was the most commonly injured organ in our study followed by Spleen and liver.

Role of Magnetic resonance hysterosalpingography in female infertility

Background: Approximately 15 % of couples are affected by infertility, which is defined as the inability to conceive after 12 months of regular unprotected sexual intercourse. Magnetic resonance imaging (MRI) can be used to evaluate congenital Müllerian duct anomalies and to diagnose adenomyosis, leiomyoma and endometriosis. MRI-hysterosalpingography (MR-HSG) in addition to conventional MRI (with/without contrast) is effectively used in diagnosing the tubal and uterine cause of infertilities. Materials and methods: The purpose of study was to evaluate the ability of magnetic resonance hysterosalpingography to evaluate fallopian tube patency and evaluate cause of infertility. Written informed consent was obtained from all subjects. Forty two women with infertility were recruited between 2017 and 2018. Eighteen out of 42 patients had already underwent conventional hysterosalpingography. MRI was performed on a 1.5-T System, using a phased array surface coil. Results: About 32 patients showed bilateral tubal patency. Six patients showed bilateral tubal occlusion on MR HSG. 2 patients had unilateral tubal occlusion. 7 patients had ovarian endometriosis, 6 had leiomyomas, 2 patients had mullerian anomalies, 3 patients had features of polycystic ovarian disease and 5 patients had multifactorial etiology. No cause could be found in 9 patients. Conclusion: MR-HSG is a feasible, useful, innovative and well tolerated tool for the assessment of the uterus, fallopian tubes, ovaries and extra-uterine structures. MR-HSG is a new promising imaging approach to female infertility. MR-HSG scanning can be helpful in demonstrating tubal patency even in patients with documented tubal blockage on conventional HSG.

Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer

The goal of this investigation was to develop and demonstrate a polymer/paclitaxel self-assembly (PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone (PVP)-based PTX-SAs (PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTX-SAs exhibited less toxicity to human red blood cells indicating a suitable formulation for reducing systemic toxicity. The formation of PVP and PTX self-assemblies was confirmed using fluorescence quenching and transmission electron microscopy which indicated that the PVP/PTX-SAs were spherical in shape with an average size range of 53.81 nm as detected by transmission electron microscopy (TEM). FTIR spectral analysis demonstrates incorporation of polymer and paclitaxel functional groups in PVP/PTX-SAs. Both proliferation (MTS) and clonogenic (colony formation) assays were used to validate superior anticancer activity of PVP/PTX-SAs in breast cancer cells over paclitaxel. Such superior anticancer activity was also demonstrated by downregulation of the expression of pro-survival protein (Bcl-xL), upregulation of apoptosis-associated proteins (Bid, Bax, cleaved caspase 7, and cleaved PARP) and -tubulin stabilization. These results support the hypothesis that PVP/PTX-SAs improved paclitaxel delivery to cancer cells.

Effect of long-term exposure to sublethal concentration of imidacloprid on some biochemical and haematological parameters of Grass carp and Goldfish

During the present research, C. idella and C. auratus fish were exposed to 2-ppm concentration of imidacloprid for 28 and 24 days, respectively, and the effect on biochemical and haematological parameters was investigated. During the study of biochemical parameters, there occurred significant increase [P<0.05] in the serum levels of ALT and creatinine of imidacloprid exposed groups of both species of fish. The level of serum albumin of imidacloprid exposed groups of both fish species was significantly lower as compared to control group [P<0.05]. Serum globulin level in imidacloprid exposed group of C. idella was insignificantly lower as compared to control group, however the serum globulin level of C. auratus was significantly lower than the control group [P < 0.05]. The level of total proteins in serum of imidacloprid exposed groups of both fish species was insignificantly lower as compared to control groups [P> 0.05]. During the study of haematological parameters, TLC of C. idella was insignificantly [P>0.05] higher than control group but the TLC of C. auratus was significantly [P<0.05] higher than control. There was also observed increasing trend in the percentage of neutrophils and lymphocytes of imidacloprid exposed group of each fish species. The platelets count of imidacloprid exposed group of each fish species was significantly [P<0.05] lower than control group. The haemoglobin concentration of imidacloprid exposed group of C. idella was significantly lower than control group [P<0.05]. In case of C. auratus, the haemoglobin level of imidacloprid exposed group was insignificantly lower than control group [P>0.05]. From the finding of the present research it was concluded that 28 days exposure of C. idella and 24 days exposure of C. auratus to 2 ppm concentration of imidacloprid does not cause mortality however the exposure causes alteration in the normal level of biochemical and haematological parameters

Pleomorphic Xanthoastrocytoma: clinicopathological spectrum of an intriguing neoplasm

Background and Objective: Pleomorphic xanthoastrocytoma [PXA] is a rare primary WHO Grade II astrocytic tumor comprising of < 1% of all astrocytomas. It is generally benign and slow growing however disease progression and malignant transformation with anaplastic features have been infrequently reported. Our objective was to assess clinicopathological characteristics of this rare tumor at our center

Methods: A retrospective study was conducted at Aga Khan University Hospital from January 1992 till January 2016. Data was entered on a proforma including patient demographics, clinical features, tumor location, histological features and follow-up, where available

Results: Forty Seven cases of PXA were retrieved during the study period. The mean age was 23.8 years [SD=15.1] and median age was 19 years. The most frequent symptom was head ache [n=31]. Male were more frequently affected [n=26]. The commonest location was temporal lobe. On microscopic examination, tumors were pleomorphic without mitoses or necrosis, however two cases showed increased mitotic activity, and one case revealed associated gliosarcoma. Follow-up of only 29 cases was available for a period ranging between 2 and 184 months [85 months +/- 56 months]. Outcome was good in 27 patients with the last follow up showing no radiographic or clinical evidence of tumor recurrence

Conclusions: PXA is an infrequent tumor in our population also, with less than 50 cases identified in two decades study period. Due to its rarity and its bizarre histomorphology, it should be diagnosed correctly, as it has got better prognosis than other astrocytic tumors

Post-chemotherapy neuroblastoma-like differentiation in ewing sarcoma of humerus: report of a rare case with review of literature

A 21-year patient initially presented with a fracture of the humerus following minor trauma. A bone scan and biopsy were done due to the suspicion of pathological fracture and the biopsy confirmed the diagnosis of Ewing Sarcoma [EWS]. Two months after initial presentation, chemotherapy was started and 5 cycles were given over a span of 6 months. Surgical resection of the tumor was then performed. The post-chemotherapy resection specimen, on histological examination, showed the presence of areas of neuroblastoma-like differentiation in otherwise morphologically classic EWS. Cytogenetic analysis by FISH revealed EWSR1 gene rearrangement. Four similar cases have been reported earlier in literature, all in females below 20 years of age. Our case is unique as it is the first case of post-chemotherapy neuroblastoma-like differentiation of EWS in a 21-year male

Olfactory neuroblastoma: a clinicopathological experience of a rare entity from Pakistan

Objectives: To present the clinicopathological experience of Olfactory Neuroblastoma [ONB] with emphasis on histopathological and immunohistochemical features

Methods: A descriptive cross-sectional study was done on 36 cases of ONB, selected by non-probability purposive sampling. Theses cases of ONB were retrieved and reviewed from surgical pathology database of Aga Khan University Hospital reported between January 1993 and March 2015

Results: Tumor size and age of presentation was wide in range without any distinct bimodal distribution. Nasal cavity was most common site along with involvement of paranasal sinuses. More than 50% cases had Kadish stage A. Microscopically, most cases were Grade-1 and majority showed partial or complete lobular architecture. Neurofibrillary matrix was observed in 2/3rd of cases. Among immunohistochemical markers, Neuron Specific Enolase was most frequently expressed. Unusual positive expression of Cytokeratin AE1/AE3 and Cytokeratin CAM5.2 was also seen focally in few cases

Conclusion: The ONB has great variability of histological and clinical presentation, and immunohistochemical markers are useful to differentiate from more common small round blue cell tumours of nasal cavity

In vitro Screening of Some Indian Medicinal Plants for Their Activity against Extended Spectrum Beta Lactamases.

Context: Extended Spectrum Beta Lactamases (ESBLs) play an important role in pathogenesis of various infections by enabling the bacterial species to be resistant to β-lactam antibiotics including extended-spectrum cephalosporins. Plants were selected on the basis of their traditional applications. Objective: Our investigation screens and evaluates15 Indian medicinal plants for antimicrobial efficacy and synergistic potential against ESBLs producing bacteria. Materials and Methods: 6 bacterial strains were screened for their ability to release ESBLs. Plant extracts in methanol and aqueous solvents were screened for their effect on ESBLs producing bacteria. Antimicrobial-linked ESBLs inhibition activity and minimum inhibitory concentration (MIC) of extracts were evaluated by agar well diffusion and microdilution method. Synergistic interactions between plant extracts exhibiting good antimicrobial activity and extended spectrum cephalosporins were explored by Checkerboard method. Results: Three strains were detected as ESBL positive. The results of susceptibility assay clearly showed strong ESBLs inhibitory effect of Crinum latifolium, Oroxylem indicum, Punica granatum, Sapindus emarginatus and Terminalia chebula and their MIC values ranged from 1.87-30 mg/ml. In vitro interactions between plant extracts and antibiotics cefotaxime and ceftaizidime evaluated in terms of fractional inhibitory concentration (FIC) indices indicated synergism. Discussion and Conclusion: Higher resistance of ESBLs positive strains to β-lactam antibiotics encourages us to search the novel ESBLs inhibitors. Maximum 10-fold decline in the MIC of antibiotics cefotaxime and ceftaizidime was achieved in combination with plant extracts. Owing to enormous clinical significance of ESBL-producing organisms coupled with limited therapeutic options, the results revealed by present study are of paramount importance.

Sweet's syndrome: an evidence-based report

Sweet's syndrome encompasses a variety of neutrophilic dermatosis characterized by acute onset of erythematous, edematous, painful papules, plaques and nodules associated with systemic symptoms, peripheral blood leukocytosis and histological findings of dense neutrophilic infiltrate. Ten patients were diagnosed during a period of one year. The patient population consisted of 7 females and 3 males with mean age of 47.6 years ranging from 32 to 60 years. An associated disorder was observed in 6 patients which were diabetes, hypothyroidism, hypertension and inflammatory bowel disease. Two cases of pregnancy associated disease were observed. Cutaneous lesions consisted of erythematous plaques or nodules. Lesions were located mainly on the face, neck and upper extremities. All biopsy specimens demonstrated a dermal infiltrate composed predominantly of neutrophils. Seven patients were treated by oral corticosteroids and three by oral dapsone, all for a period of 6 weeks

Symptomatic surgically treated non-neoplastic cysts of the central nervous system: a clinicopathological study from Pakistan

To report clinicopathologic features of symptomatic surgically removed non-neoplastic cysts of the central nervous system [CNS]. Case series. The Aga Khan University Hospital, Karachi, from 2003 to 2012. All non-neoplastic CNS cysts reported during the study period were retrieved and reviewed. Age, gender, location, histologic type and clinical features were noted. A total of 124 cysts were diagnosed in the study period. These included 44 epidermoid cysts [mean age 30.5 +/- 13.8 years], 35 colloid cysts [mean age 31 +/- 13.2 years], 32 arachnoid cysts [mean age 24.8 +/- 20.2 years], 6 dermoid cysts, 3 enterogenous cysts and Rathke's cleft cysts each and 1 ependymal cyst. All cyst types mainly presented in young adults in both genders with signs and symptoms of a mass lesion. Non-neoplastic cyst mainly presented like a CNS mass lesion in young adults. Epidermoids were the most common type of these cysts in the present series followed by the colloid and the arachnoid cysts

Larvicidal, insecticidal, brine shrimp cytotoxicity and anti-oxidant activities of Diospyros kaki [L.] reported from Pakistan

Diospyros kaki is cultivated in different agro-ecological zones of Pakistan, especially in Malakand division. The current study was designed to investigate the hide potential of the vulnerable species of the plant. Aqueous extracts of Diospyros kaki leaves were screened for larvicidal, insecticidal cytotoxic and antioxidant activities. The extract exhibited moderate to outstanding larvicidal activity [100 to 28%] at 100, 80, 70, 50, 40, 30, 20 and 10% concentrations respectively after 24 hours, showing 42% LCso. Permitrin displayed 100% lethality at 0.3%. The extract demonstrated outstanding cytotoxic action against brain shrimps nauplii [Artemia salina], showing 10 ppm LC[50] which is closed to the LC[5]o [9.8jtig/ml] of standard drug Etoposide. Similarly profound insecticidal potential [100%] was recorded after 15 min against Cimex lectularius. In DPPH scavenging activity the extract demonstrated moderate 30.22%, while Quercetin, Gallic acid and Acetic acid showed 98, 96 and 97% activity respectively at lOOppm. Thus on the basis of our finding it could be concluded that the decoction of the leaves of D. kaki is a good natural alternative for the control of insects and neoplasia

In vitro and in silico Approach to Evaluate the Urease and Collagenase Inhibitory Activity of Embilica officinalis Gaertn Fruit.

Aim: The key virulent factors of bacteria are enzymes. Urease and collagenase enzyme play a vital role in pathogenesis of wide array of bacterial strains and cause numerous diseases. So the aim of present study was to find out the potent drug candidate from Emblica officinalis Gaertn. fruit for these pathogenically important enzymes. Study Design: A study was done to screen out the bacteria producing urease and collagenase from a stack of 19 bacterial strains and the positive strains were checked for their susceptibility to methanol and ethyl acetate extracts of Emblica officinalis Gaertn. fruit. Further extracts were investigated for their potential to antagonize these enzymes. Place and duration of study: Department of Biotechnology KUK, Jwahar Lal University, Delhi between February 2012 and December 2013. Methodology: Screening of bacteria and their susceptibility to methanol and ethyl acetate extracts of E. officinalis was done by using agar diffusion assay. Further investigation of extracts to antagonize urease and collagenase enzymes was checked by using phenol hypochlorite and gelatin diffusion assay respectively. GC-MS analysis, docking and ADME studies were conducted to screen for plant-based urease and collagenase inhibitors. Results: Methanol extract inhibited Jack bean urease enzyme (IC50:0.74 mg/ml) more potently than collagenase Type 1 (IC50:1.13 mg/ml), while ethyl acetate extract inhibited collagenase completely (IC50:4.19 mg/ml) and was observed to be more effective than methanol extract (IC50:5.51 mg/ml). GC-MS analysis revealed an array of 28 and 30 compounds in methanol and ethyl acetate extract respectively. In silico study identified xylenol and erucylamide as active compounds of E. officinalis having good binding score with better ADME properties compared to standard compounds. Conclusion: So our observations find application for the consideration of E. officinalis compounds for further validation towards development of effective drugs against these significant bacterial enzymes.

Antibacterial, Synergistic and β-lactamase Inhibitory Activity of Oroxylem indicum: An In vitro and Molecular Interaction Study.

Aims: The study was aimed to evaluate the antibacterial, synergistic and β-lactamase inhibitory potential of O. indicum against ampicillin resistant and Extended Spectrum β- lactamase (ESBL) producing bacterial strains. Methods: Bacterial strains were screened for ampicillin resistance and ESBL production by disk diffusion method and modified double disc synergy test respectively. Antibacterial and synergistic activities of O. indicum methanol extract and ethyl acetate sub fraction of methanol extract were explored by agar well diffusion method and Checkerboard method respectively. Extracts were subjected to Gas chromatography and Mass spectroscopy (GC-MS) analysis to identify the bioactive compounds. Molecular docking studies were carried out to verify the β-lactamase inhibitory potential of the bioactive compounds. Results: All bacterial strains were found to be resistant to ampicillin and only one strain was detected as ESBL positive. Ethyl acetate sub fraction exhibited strong antibacterial and synergistic activity than the methanol extract. Zone of inhibition and Minimum inhibitory concentration for ethyl acetate sub fraction was 16 mm and 15mg/ml respectively. In vitro interactions between plant extracts and ampicillin evaluated in terms of fractional inhibitory concentration (FIC) indices revealed synergistic effects of plant extracts. The molecular docking studies of major bioactive compounds depicted by GCMS analysis revealed that Wogonin, a flavonoid (GLIDE Score-5.77) possessed the best inhibitory profile against β–lactamase. Conclusion: Synergistic activity of O. indicum may be attributed to the β–lactamase inhibitory potential of the bioactive compounds present in the extract. The findings provide substantial basis for the future use of O. indicum crude extracts as potential antibacterial and antibiotic modulating agent.

Temperament and character in victims of school bullying

Background: Bullying involves repeated and over time targeted intimidation or humiliation. The bully can resort to a number of aggressive behaviours to make the target or victim feel powerless. However, bullying entails more than aggression: a power imbalance exists between the bully and the target .Bullying takes place among young children as well as adults in a variety of settings, but most of the research focuses on children and youth in schools. Aim: To evaluate temperament and character in victims of school bullying in comparison with a control group using the Junior Temperament and Character Inventory. Method: 41 victims of school bullying and 40 control group participants between the ages of 8 and 17 years studying in English medium schools in South Delhi were included in the study. Participants were excluded if participants were younger than 8 years, could not read English and parental consent was not obtained. Illinois Bully Scale and the Junior Temperament and Character Inventory was administered to the participants. Results: According to child and parent data, victims of school bullying had lower scores on self-directedness, cooperativeness, reward dependence and persistence compared with control group and significantly higher scores on novelty seeking and harm avoidance .According to parent data only, victims of school bullying significantly differed from a control group on self-transcendence with higher fantasy scores and lower spirituality scores. Conclusion: Victims of school bullying have a different temperament and character profile compared to control group .Hence, up to a certain age there is still a potential for changing some temperamental characteristics, and consequently timely interventions could prevent the onset of victimization or minimize the severity of clinical outcomes in school children

Some unfavorable intraoral features in edentulous patients reporting for complete denture treatment at the prosthodontics department of a teaching dental hospital

Introduction and Objectives: To gain an insight into the prognosis of complete denture treatment, the dental practitioner must be familiar with the anatomical and physiological condition of edentulous mouth of each individual patient. This study reports frequencies of some common unfavorable intra-oral features in edentulous patients reporting for complete denture [CD] treatment at the Prosthodontics Department, Khyber College of Dentistry [KCD] Peshawar [Pakistan]

Methodology: This was a descriptive, cross sectional study conducted during the period from February 2011 to February 2013.Using pre-structured data collection sheet, information of some unfavorable intraoral features of edentulism was recorded from patients seeking consultation for complete denture therapy in both jaws for the first time. History, clinical and radiographic examinations were the method for assessing the unfavorable intraoral features including mandibular bone height, maxillary residual ridge morphology, pattern of muscle attachment and maxillo-mandibular relationship

Results: Mean age was 61.8 +/- 9 years with male to female ratio of 1.27. Patients easy-to-treat with conventional CDs were 43 [27%] as compared to 116 [73%] who were difficult-to-treat. The frequencies of unfavorable features including mandibular bone height, maxillary residual ridge morphology, pattern of muscle attachment and maxillo-mandibular relationship were 60 [37.7%], 40 [25%], 54 [34%] and 55 [34.6%] respectively. Females had significantly reduced mandibular bone height

Conclusion: The high frequency of unfavorable intraoral features suggests screening of edentulous patients for knowing their levels of treatment complexity with conventional complete dentures

Determining the oral surgery confidence and factors influencing non compliance with pre-prosthetic surgery

The objective of this study is to determine the factors responsible for noncompliance in pursuing preprosthetic surgery and baseline oral surgery confidence amongst patients reporting to Khyber College of Dentistry, Peshawar. This cross sectional analytical study was carried out at the Department of Prosthodontics at Khyber College of Dentistry, Peshawar. Informed consent was taken from the patients participating in the study. A custom made proforma was made to note demographic variables for comparison with the Litt's Oral Surgery Confidence Questionaire [OSCQ], the type of preprosthetic surgery required and factors influencing noncompliance with the said procedure namely increased treatment duration, local and systemic morbidity, associated expenses, failure of surgery and myths heard or believed. Scoring of the OSCQ was done from 0-9 on 11 items and total score calculated. T-test was used to determine significance of gender and level of education with OSCQ score [p-value <0.05]. One way ANOVA was utilized to determine significance of age and required procedure with OSCQ score [p-value <0.05]. 105 patients comprised the study sample with a M:F ratio of 1:1.05. The mean age of the sample was 58.06 +/- 11.22 years. Illiterate patients accounted for 82.9%. Alveoloplasty was the most commonly prescribed procedure [56.2%]. Local and systemic morbidity was the most common factor leading to noncompliance in undergoing preprosthetic surgery [29.5%]. The mean OSCQ score was 46.61 +/- 11.91. Gender and level of education were found to have a significant relationship with OSCQ scores [[p-value <0.05] whereas age and procedure required did not show the same with OSCQ scores [p-value >0.05]. Illiteracy was the predominant educational state amongst the sample and alveoloplasty was the most commonly prescribed procedure alone and also in combination with other procedures. Moderate confidence level was noted in undergoing oral preprosthetic surgery. Gender and educational levels showed a significant relationship with OSCQ scores and these are the areas that should be focussed on to improve compliance in pursuing pre-prosthetic surgery which in turn can improve satisfaction with the use of complete dentures